Sarcoplasmic Reticulum-Mitochondrial Symbiosis
نویسندگان
چکیده
منابع مشابه
Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points.
Propagation of ryanodine receptor (RyR2)-derived Ca(2+) signals to the mitochondrial matrix supports oxidative ATP production or facilitates mitochondrial apoptosis in cardiac muscle. Ca(2+) transfer likely occurs locally at focal associations of the sarcoplasmic reticulum (SR) and mitochondria, which are secured by tethers. The outer mitochondrial membrane and inner mitochondrial membrane (OMM...
متن کاملSarcoplasmic Reticulum
Fragmented sarcoplasmic reticulum (FSR) membranes isolated from rabbit skeletal muscle are impermeable to inulin-(14)C (mol wt 5,000), and dextran-(14)C (mol wt 15,000-90,000) at pH 7.0-9.0, yielding an excluded space of 4-5 microl/mg microsomal protein. In the same pH range urea and sucrose readily penetrate the FSR membrane. EDTA or EGTA (1 mM) increased the permeability of microsomes to inul...
متن کاملThe Sarcoplasmic Reticulum
The contents of this volume, and most especially the modern morphological observations on the sar-coplasmic reticulum, place in strong relief the neglect that was accorded this component of the sarcoplasm in the 30 to 40 years preceding its recent rediscovery. From the time of publication of Veratti's paper, as D. S. Smith points out in his historical survey (54), various related or unrelated c...
متن کاملLamellar Junctional Sarcoplasmic Reticulum
This report deals with a description of an assembly of lamellar structures that have a morphology indistinguishable from that of cardiac junctional (1) and extended junctional (2) sarcoplasmic reticulum (SR). Briefly, junctional SR, a normal component of all myocardial cells, is that specialized portion of the SR which is periodically attached to sarcolemma by processes (junctional processes) i...
متن کاملSarcoplasmic Reticulum Luminal [Ca
The role that sarcoplasmic reticulum (SR) luminal Ca 2+ concentration plays in regulating ryanodine receptors (RyRs) is considered to be very important in process of cardiac excitation-contraction coupling. Here we developed a multi-scale mathematical model by coupling a two-dimensional spatio-temporal Ca 2+ reaction-diffusion model with an action potential model of the ventricular myocyte. The...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Exercise and Sport Sciences Reviews
سال: 2009
ISSN: 0091-6331
DOI: 10.1097/jes.0b013e3181911fa4